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Listing Auto-Immune Disease

June 16, 2013

Auto Immune 2Autoimmune disease

Autoimmune diseases are chronic degenerative and/or inflammatory conditions that result from abnormal immune reactions to compounds absorbed from the environment. The normally defensive action of the immune system becomes destructive, whereby healthy body tissues are damaged by the immune defense mechanisms. Symptoms of autoimmune diseases are specific to the particular type of autoimmune disease; however, typically tissue damage and inflammation are always present.
Included or related conditions include:

 Rheumatoid arthritis (RA)
 Systemic lupus erythematosus (SLE)
 Mixed connective tissue disease (MCTD)
 Scleroderma
 Ankylosing spondylitis
 Multiple sclerosis (MS)
 Polyarteritis nodosa (PAN)
 Thromboangitis obliterans (Buerger’s disease)
 Behcet’s syndrome
 Hashimoto’s thyroiditis
 Grave’s disease
 Insulin resistance
 Polymyalgia rheumatica (PMR)
 Polymyositis
 Dermatomyositis
 Sjogren’s syndrome
 Vitiligo
 Pemphigus
 Vasculitis, etc.

Some other possibly autoimmune-related conditions include primary biliary cirrhosis, chronic active hepatitis, urticaria, asthma, atopic dermatitis, psoriasis, interstitial cystitis, some cases of infertility, glomerulonephritis, fibromyalgia, chronic fatigue syndrome, etc.

Technical Description

Autoimmune diseases result from abnormal immune-mediated reactions that occur when the immune system is overwhelmed by systemic exposure to exogenous foreign substances (antigens) that may result in immunocomplex (antibody-antigen) formation with deposition at “predisposed” tissue sites according to the affected individual’s susceptibility; some of these foreign substances may display similar antigenic sequences to the patients own tissue HLA (auto-recognition marker) substances (antigens) resulting in the activation of mediators of inflammation and spasm including alternate complement, histamine, leukotrienes, prostaglandins, kinins, reactive oxygen species, nitric oxide, hyaluronidase, elastase, collagenase and platelet-activating factor.


The body’s first defense against potential allergens is physical exclusion (non-specific defense) via the epidermal mantle and mucus membrane secretions of epithelial tissues. Production and maintenance of these tissue structures differs in relation to genetic and lifestyle factors. Potential antigens (environmental compounds that can provoke abnormal inflammatory immune reactions in susceptible individuals) include pollens, chemicals, foods, medications, microbial constituents and environmental concerns. It is important to note that HLA antigen expression DR3/B8 is only present in a small percentage of autoimmune patients. Oral contraceptives can exacerbate connective tissue diseases.


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